To test experimental drug for laminitis in horses
November 14, 2012
Veterinarians at the University of California, Davis, School of Veterinary Medicine have announced plans to conduct the first clinical trial of an experimental drug that has shown promise in treating horses stricken with laminitis, an excruciatingly painful and often life-threatening foot-related disease. Four horses suffering from laminitis have been treated with the investigational anti-inflammatory drug so far. One experienced a complete remission that has lasted for more than a year, and three others have shown some improvement.
A paper on the first laminitis case has been accepted for publication by the peer-reviewed Journal of Veterinary Anaesthesia and Analgesia. The horses were treated under a "compassionate use" protocol approved by the UC Davis Institutional Animal Care and Use Committee. That protocol allows animals to be treated with an experimental drug if no approved alternative treatment exists. A clinical trial to assess the drug's safety and establish a tolerable dose for the compound is expected to begin in the spring. Further clinical trials would be needed to establish the drug's effectiveness as a laminitis treatment.
The experimental compound, known as t-TUCB, belongs to a group of anti-inflammatory compounds called sEH (soluble epoxide hydrolases) inhibitors. It stems from a discovery made more than 40 years ago by Professor Bruce Hammock while doing basic insect biology research. Originally interested in finding biological insect control methods, Hammock has since broadened his research to also search for biomedical applications. He and colleagues have identified a group of anti-inflammatory compounds, including the sEH inhibitors, that have proven to be effective in relieving inflammatory discomfort and pain related to nervous system disorders in mice and rats. Their work has been published in scientific journals including the Proceedings of the National Academy of Sciences and the Journal of Medicinal Chemistry.
Lab alumnus won award for research paper
September 21, 2012
Food chemist and toxicologist Nils Helge Schebb, a former postdoctoral researcher in the Hammock lab (2009-2011), has just received an award from the section of liquid chromatography mass spectrometry (LC/MS) of the German Society of Mass Spectrometry for a research paper published on the anti-microbial and environmental contaminant, triclocarban (TCC).
Schebb received the award, the 2012 Sciex LC /MS Award, for his “extraordinary work in the field of LC/MS” on Sept. 18 during the German society’s workshop in Wuppertal, Germany. The award includes a prize of 3000 Euros about $4,500from AB Sciex, a major producer of MS systems for a host of applications, including drug discovery, clinical research, food production, and toxicology.
Schebb, who has a doctorate in analytical chemistry from the University of Munster, Germany, is now principal investigator and head of a lab at the Institute of Food Toxicology and Chemical Analysis at the University of Veterinary Medicine Hannover in Hannover, Germany (link to the website: schebb-web.de).
The research, “Investigation of Human Exposure to Triclocarban after Showering and Preliminary Evaluation of its Biological Effects,” was published in the journal Environmental Science and Technology and was co-authored by Hammock and four other scientists in the Hammock lab: Bora Inceoglu, KC Ahn, Christophe Morisseau and Shirley Gee.
The awarded study measured the human exposure with TCC by the use of personal care products. “It was a surprise that a single shower led to such high urinary concentration of TCC metabolites” Schebb said. Moreover, the study revealed that TCC strongly inhibits the enzyme soluble epoxide hydroxylase (sEH), suggesting that exposure could impact human health. The Hammock lab has published a series of studies on the efficacy of sEH suppression in the regulation of blood pressure, inflammation, and pain. “ Though sEH inhibition has largely beneficial effects on mammalian physiology, these is not an action the consumer expect from the use of a personal care product”. Schebb commented on these results.
Since the publication of the 2011 study, Schebb has been involved in five follow-up studies on TCC, showing for example that TCC also can form reactive metabolites which covalently bind to cellular macromolecules.
Schebb’s award-winning study was one of some 15 toxicological and laboratory methods papers he has co-authored on work with the Hammock group.
Let's get everybody wet
July 13, 2012
It was meant to be 15 minutes of fame, but it turned out to be 10 minutes of aim. That’s how long it took for the water warriors at the 10th annual Lab Water Balloon Battle to toss 2,000 water balloons at one another.
It was a traditional time for camaraderie and to beat the heat since 2003.
The event, which began at 3 p.m. Friday on the Briggs Hall Lawn on Kleiber Hall Drive, drew scientists from five different labs. Last year the water balloon war lasted 15 minutes, but this year, all the ammunition was gone after 10 minutes.
Every year, faculty, staff, students, children and spouses are welcome to participate or watch. The only requirement to participate: They have to help fill the water balloons.
Jiawen awarded the Henry A. Jastro Research Award
Great News! Our graduate student, Jiawen Xu, has been selected as one of the Henry A. Jastro Research Award recipients for 2012-13. This award is awarded to outstanding graduate students in recognition of their potential to carry out research projects related to the missions of the College of Agricultural and Environmental Sciences.
Leaving for good
It's always sad to say goodbye. Hee Joo Kim (left), the research associate who has been working in the lab for 7 years, is taking up a new position in a pharmaceutical company in Bay Area. Yonghao Ye (right) is returning China after one year visit in Hammock Lab.
"From Entomology Discovery to New Medication"
Dr. Hammock's research is featured in CA&ES Impact.
Shirley gives talk to the WCAHS
Our senior research associate Shirley Gee will speak on “Advances in Immunoassays for Pesticide Detection” from 4 to 5 p.m., Monday, March 5 at the Western Center for Agricultural Health and Safety (WCAHS) seminar.
Lab celebrates end of the 2011
Merry Christmas!! We have a potluck party on 12/21 to celebrate winter break! More than 20 dishes were served.